I always try to consult the man pages for these kind of questions (you can search by typing ‘/’ in the man page). Here’s what the systemctl manual has to say in the specifications for the --force option:

Note that when --force is specified twice the selected operation is executed by systemctl itself, and the system manager is not contacted. This means the command should succeed even when the system manager has crashed.

Nope, not at all. Silverblue here (GNOME), and the upgrade went smooth, nvidia drivers and all.