I don’t know about first but when I was young I played a pair of animated point and click educational games called Dino Dudes and Space Dudes. Years later I tried to find copies of them and there super rare, turns out (from memory) they were developed in Australia and not widely distributed in a time where not everything made its way onto the internet.

I did manage to find a freeware copy of both games online but the effort to get them running turned me off of the endeavour.